Isaac married Susan Emily Irvin on 2 Jun 1923 in Eugene, Lane, Oregon, USA. Susan (daughter of George W. Irvin and Catherine Janet Montgomery) was born on 21 Oct 1888 in Prairieville, Brown, Minnesota, USA; died on 23 Jan 1919 in Eugene, Lane, Oregon, USA. [Group Sheet] [Family Chart]

1. Harold Francis Holmes was born on 31 Jan 1913 in Walterville, Lane, Oregon, USA; died on 17 Sep 1966 in Tucson, Pima, Arizona, USA.
2. Doris Sara Holmes was born on 29 Mar 1914 in Star, , Oklahoma; died on 14 Jul 1981 in Seattle, King, Washington, USA.
3. Living
4. Lois Rhoda Holmes was born on 9 Oct 1916 in Walker, , Oregon; died on 21 Feb 1986 in Bellevue, King, Washington, USA.